Hereditary cancers are cancers that are more likely to occur due to inherited genetic mutations passed down from parents to children. Inheriting a gene mutation does not guarantee the development of cancer, but it does increase the likelihood compare

Hereditary cancers are cancers that are more likely to occur due to inherited genetic mutations passed down from parents to children. Inheriting a gene mutation does not guarantee the development of cancer, but it does increase the likelihood compared to those without a mutated gene.A DNA test can help identify cancer-causing mutations in genes. For instance, having a specific mutation in the BRCA1 gene increases the genetic risk of developing breast cancer. This risk applies to males as well, as the mutation can cause male breast cancer. However, it is important to note that more than 80% of men are unaware of this risk. Moreover, this inherited genetic condition can be passed down to daughters, further increasing their genetic risk of breast cancer. Knowing your genetic risk empowers not only you but also your family to take preventive measures, such as early cancer screenings for those at higher genetic risk. Sharing your DNA results with loved ones can be beneficial, as increased risk in one family member suggests a potential heightened risk in others.At Circle, we believe in empowering individuals to take control of their health by understanding their genetic blueprint. Through the use of next-generation sequencing technology, we analyze DNA samples to identify genetic risks for 36 cancers, including breast, ovarian, colorectal, lung, liver, pancreas, and more. Knowing your risk and taking advantage of early screening and detection can have obvious benefits. For many cancers, early detection can significantly increase survival rates to over 90%.

What are hereditary cancers?

Carrier screening is a genetic test that can help determine if you carry a mutation for specific inherited genetic conditions that could be passed on to your child. Many individuals are carriers of various genetic conditions, often without experienci

<section id="isPasted">Carrier screening is a genetic test that can help determine if you carry a mutation for specific inherited genetic conditions that could be passed on to your child. Many individuals are carriers of various genetic conditions, often without experiencing any symptoms or affecting their own health. However, when two carriers for the same genetic condition have children together, there is a 25% chance that the child will inherit two mutated genes and develop the genetic condition. These conditions, which can be detected through carrier screening, are typically severe and can result in death or serious disability during early childhood. Therefore, carrier screening plays a crucial role in reducing this risk.Examples of genetic conditions range from relatively mild ones like Deafness to more debilitating conditions such as Sickle Cell Disease (1), which can significantly impact a child&apos;s quality of life and decrease life expectancy.At Circle, we believe in the empowerment of individuals to take control of their health by providing them with knowledge about their genetic makeup. Using advanced next-generation sequencing technology, our Circle Family Planning test analyzes DNA samples to identify genetic risks for over 160 inherited genetic conditions. By knowing your and your partner&apos;s risk profiles before pregnancy, you have the opportunity to consider your options and make informed choices. Your healthcare provider can guide you through the available options.<hr>(1) Sickle Cell Disease is an inherited blood disorder that affects a crucial component of red blood cells called hemoglobin, resulting in the cells taking on a stiff crescent shape resembling a sickle. Sufficient levels of red blood cells and hemoglobin are necessary for effectively delivering oxygen to all the cells in the body. As the sickled blood cells die prematurely, inadequate oxygen delivery can cause weakness and fatigue. These sickled cells can become lodged in small blood vessels, blocking blood flow and causing serious medical complications such as tissue deterioration.</section>

What is carrier screening?

Many of us are carriers of inherited conditions and simply do not know it. Over 80% of children with inherited conditions are born to parents who aren’t aware they carry the variant. Many inherited conditions, such as Sickle Cell Disease (1) and Cyst

<span data-sheets-userformat="{&quot;2&quot;:15233,&quot;3&quot;:{&quot;1&quot;:0},&quot;10&quot;:1,&quot;11&quot;:4,&quot;12&quot;:0,&quot;14&quot;:[null,2,0],&quot;15&quot;:&quot;Arial&quot;,&quot;16&quot;:10}" data-sheets-value="{&quot;1&quot;:2,&quot;2&quot;:&quot;Many of us are carriers of inherited conditions and simply do not know it. Over 80% of children with inherited conditions are born to parents who aren&#x2019;t aware they carry the variant. Many inherited conditions, such as Sickle Cell Disease (1) and Cystic Fibrosis (2), may have no family history on either parent&apos;s side. This happens because having just one copy of a mutation does not usually cause any symptoms, so many people are \&quot;carriers\&quot; for inherited conditions without ever knowing it. Almost all of these conditions have what is called \&quot;autosomal recessive inheritance\&quot; where an affected child has to inherit a copy of a gene with the disease-causing mutation from each parent. Hence, if two people who are carriers for the same condition have children together, each child has a 1 in 4 chance of being born with the condition. \n\nIndividually, inherited conditions may be rare. However, collectively, there is at least a 1 in 3 chance that you are a carrier of at least one of the tested conditions. This is much higher than the incidence of Down syndrome. Knowing your risk profile before or early in a pregnancy allows you to consider your options with time to make choice, together with your healthcare provider. \n\nWith Circle Family Planning, we help individuals identify their genetic risk for 155+ heritable genetic conditions and provide genetic counselling to help them understand their results and possible next steps with their partner. Learn more. [1]\n\n(1) Sickle Cell Disease is an inherited blood disorder which affects a major component of red blood cells, hemoglobin, and results in red blood cells having a stiff crescent shape resembling a sickle. The sickled blood cells die permaturely, causing a person to feel weak and tired. These sickled cells can also get stuck in small blood vessels, blocking blood flow and causing serious medical complications such as tissue deterioration. \n(2) Cystic Fibrosis is a severe condition that can affect different parts of the body such as lungs, bowel, pancreas etc. This disease is caused by a gene called CFTR. When CFTR does not function well due to genetic mutation, mucus can become thick and sticky clogging passages such as breathing airways and bowel. Healthy mucus is needed for clearing germs and with thick mucus, germs can get trapped. This can cause frequent lung infections and death in childhood or early adulthood.&quot;}">Many of us are carriers of inherited conditions and simply do not know it. Over 80% of children with inherited conditions are born to parents who aren&#x2019;t aware they carry the variant. Many inherited conditions, such as Sickle Cell Disease (1) and Cystic Fibrosis (2), may have no family history on either parent&apos;s side. This happens because having just one copy of a mutation does not usually cause any symptoms, so many people are &quot;carriers&quot; for inherited conditions without ever knowing it. Almost all of these conditions have what is called &quot;autosomal recessive inheritance&quot; where an affected child has to inherit a copy of a gene with the disease-causing mutation from each parent. Hence, if two people who are carriers for the same condition have children together, each child has a 1 in 4 chance of being born with the condition. Individually, inherited conditions may be rare. However, collectively, there is at least a 1 in 3 chance that you are a carrier of at least one of the tested conditions. This is much higher than the incidence of Down syndrome. Knowing your risk profile before or early in pregnancy allows you to consider your options with time to make a choice, together with your healthcare provider. With Circle Family Planning, we help individuals identify their genetic risk for 155+ heritable genetic conditions. We also provide genetic counselling to help them understand their results and possible next steps with their partner.&#xA0; <hr><span data-sheets-userformat="{&quot;2&quot;:15233,&quot;3&quot;:{&quot;1&quot;:0},&quot;10&quot;:1,&quot;11&quot;:4,&quot;12&quot;:0,&quot;14&quot;:[null,2,0],&quot;15&quot;:&quot;Arial&quot;,&quot;16&quot;:10}" data-sheets-value="{&quot;1&quot;:2,&quot;2&quot;:&quot;Many of us are carriers of inherited conditions and simply do not know it. Over 80% of children with inherited conditions are born to parents who aren&#x2019;t aware they carry the variant. Many inherited conditions, such as Sickle Cell Disease (1) and Cystic Fibrosis (2), may have no family history on either parent&apos;s side. This happens because having just one copy of a mutation does not usually cause any symptoms, so many people are \&quot;carriers\&quot; for inherited conditions without ever knowing it. Almost all of these conditions have what is called \&quot;autosomal recessive inheritance\&quot; where an affected child has to inherit a copy of a gene with the disease-causing mutation from each parent. Hence, if two people who are carriers for the same condition have children together, each child has a 1 in 4 chance of being born with the condition. \n\nIndividually, inherited conditions may be rare. However, collectively, there is at least a 1 in 3 chance that you are a carrier of at least one of the tested conditions. This is much higher than the incidence of Down syndrome. Knowing your risk profile before or early in a pregnancy allows you to consider your options with time to make choice, together with your healthcare provider. \n\nWith Circle Family Planning, we help individuals identify their genetic risk for 155+ heritable genetic conditions and provide genetic counselling to help them understand their results and possible next steps with their partner. Learn more. [1]\n\n(1) Sickle Cell Disease is an inherited blood disorder which affects a major component of red blood cells, hemoglobin, and results in red blood cells having a stiff crescent shape resembling a sickle. The sickled blood cells die permaturely, causing a person to feel weak and tired. These sickled cells can also get stuck in small blood vessels, blocking blood flow and causing serious medical complications such as tissue deterioration. \n(2) Cystic Fibrosis is a severe condition that can affect different parts of the body such as lungs, bowel, pancreas etc. This disease is caused by a gene called CFTR. When CFTR does not function well due to genetic mutation, mucus can become thick and sticky clogging passages such as breathing airways and bowel. Healthy mucus is needed for clearing germs and with thick mucus, germs can get trapped. This can cause frequent lung infections and death in childhood or early adulthood.&quot;}">(1) Sickle Cell Disease is an inherited blood disorder which affects a major component of red blood cells, haemoglobin, and results in red blood cells having a stiff crescent shape resembling a sickle. The sickled blood cells die prematurely, causing a person to feel weak and tired. These sickled cells can also get stuck in small blood vessels, blocking blood flow and causing serious medical complications such as tissue deterioration. (2) Cystic Fibrosis is a severe condition that can affect different parts of the body such as the lungs, bowel, pancreas etc. This disease is caused by a gene called CFTR. When CFTR does not function well due to genetic mutation, mucus can become thick and sticky clogging passages such as breathing airways and bowel. Healthy mucus is needed for clearing germs and with thick mucus, germs can get trapped. This can cause frequent lung infections and death in childhood or early adulthood.

Do I need carrier screening if my family does not have history of inherited conditions?

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Learn about hereditary conditions

What are hereditary cancers?

What is carrier screening?

Do I need carrier screening if my family does not have history of inherited conditions?